Design, synthesis and biological evaluation of a new bridged immunosuppressor.

نویسندگان

  • Z Szewczuk
  • A Wilczyński
  • I Petry
  • I Z Siemion
  • Z Wieczorek
چکیده

A bridged peptide with the sequence: H-Thr-Pro-Gln-Arg-Gly-Asp-Val-gamma-Abu-Asn-Asp-Gln-Glu-Glu-Thr-Thr-Gly-Val-Val-Ser-Thr-Pro-Leu-Ile-Arg-Asn-Gly-OH was designed to mimic the discontinuous epitope of the HLA-DQ molecule that might interact with CD4. The bridged peptide revealed distinct suppressory effect in the humoral immune response. This result supports our suggestion that the 164-172 region of the HLA-DQ molecule may enhance its interactions with coreceptors, possibly with CD4.

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عنوان ژورنال:
  • Acta biochimica Polonica

دوره 48 4  شماره 

صفحات  -

تاریخ انتشار 2001